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E-mail: info@openaccessebooks.com

ISBN: 978-93-87500-05-1

Open Access eBooks is inviting researchers working in the areas of hepatitis to submit their book chapter for the publication in volume 1 of an eBook Hepatitis: A Global Health Concern.

All book chapters undergo review process and published content is available in PDF & HTML formats.

Benefits of publishing with us:

Universal Access: eBooks published in Open Access eBooks gain international visibility. No region barriers and content is accessed by everyone across the world from our website. We also deposit published eBooks in different databases.

Freely Available: Open Access eBooks follows the principles of Open Access and the content is available to the readers without any cost. Readers can read, share, and store the published ebooks/book chapters.

Copyright with Authors: As an eBook publisher, we serve researchers in publishing their valuable work after the stringent review process. However, copyright lies with authors. We follow the CC-BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/3.0/).

Different Formats: We provide eBooks in PDF and HTML formats. Both formats are user friendly and can act as per the user requirements. We put our efforts to provide other formats in future.

For more information, contact info@openaccessebooks.com

Published Chapters:

Pathology of chronic hepatitis B and chronic hepatitis C

Author(s): Faten Limaiem*; Asma Sassi; Saadia Bouraoui; Sabeh Mzabi

Chronic viral hepatitis is a syndrome of persisting hepatotropic viral infection usually associated with chronic inflammation, hepatocyte injury and progressive fibrosis. Chronic viral hepatitis is typically classified by the responsible infecting virus and modified by the extent of pathological injury and clinical compensation. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections represent the two major causes of chronic liver disease and hepatocellular carcinoma. Despite inducing shared pathological events leading to oncogenic transformation, these two viruses present profound differences in their molecular features, life cycle and interplay with host factors, which significantly differentiate the prognostic and therapeutic approach to the related diseases. The liver injury present in chronic hepatitis may be variable, but the basic morphologic changes in all types of chronic viral hepatitis are similar. In this regard, the liver biopsy remains the gold standard and is an important tool in the evaluation of patients with liver disease.

Chronic Hepatitis B Treatment: Statu Quo and New Developments

Author(s): Julio Cesar Aguilar Rubido*; Maarten AA van de Klundert; Marie-Louise Michel

The state of the art in the field of CHB treatment reveals several limitations of currently approved therapies. Fortunately, the recent understanding of the immunology and physiology of chronic hepatitis B infection is leading to several innovative therapeutic strategies for chronic hepatitis B. Novel therapies support the global efforts by the World Health Organization in order to prevent disease progression and mortality by liver cirrhosis and hepatocellular carcinoma as a result of viral hepatitis, a disease with a mortality trend on the rise worldwide. The results of the most advanced products for chronic hepatitis B treatment will be considered in the present revision of the statu quo of therapies. Special attention is given to therapeutic vaccination. The main pharmacological and clinical trials as well as the notorious case of therapeutic vaccination in patients with viral suppression as the result of combined treatment with antivirals. These areas of research deserve in deep analysis and discussion. The products in the more advanced clinical status will be highlighted as well as the recent registration of a novel therapeutic vaccine.

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