Open Access eBooks is inviting researchers working in the areas of hepatitis to submit their book chapter for the publication in volume 1 of an eBook Hepatitis: A Global Health Concern.
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Chronic viral hepatitis is a syndrome of persisting hepatotropic viral infection usually associated with chronic inflammation, hepatocyte injury and progressive fibrosis. Chronic viral hepatitis is typically classified by the responsible infecting virus and modified by the extent of pathological injury and clinical compensation. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections represent the two major causes of chronic liver disease and hepatocellular carcinoma. Despite inducing shared pathological events leading to oncogenic transformation, these two viruses present profound differences in their molecular features, life cycle and interplay with host factors, which significantly differentiate the prognostic and therapeutic approach to the related diseases. The liver injury present in chronic hepatitis may be variable, but the basic morphologic changes in all types of chronic viral hepatitis are similar. In this regard, the liver biopsy remains the gold standard and is an important tool in the evaluation of patients with liver disease.