List of Chapters

Iron Deficiency Anaemia: the Link Between Oxidative Stress and Bone Turnover


Author(s) : Jorge Moreno-Fernandez, Julio J. Ochoa, Javier Díaz-Castro*

Iron-deficiency anaemia (IDA), one of the most common and widespread health disorders worldwide, affects fundamental metabolic functions and has been associated with deleterious effects on bone. On the other hand, oxidative stress results from an imbalance between the formation and neutralization of reactive oxygen species (ROS) and it is imposed on cells as a result of one or more of the following factors: an increase in oxidant generation, a decrease in antioxidant protection, or a failure to repair oxidative damage. During IDA oxidants are increased and antioxidants decreased, so the oxidative/antioxidative balance is shifted toward the oxidative side. Fe status is directly correlated with mineral bone density and Fe deficiency diminishes the mineral bone content, the bone mass and mechanical resistance. Fe deficiency diminishes bone matrix formation, reducing the amount of procollagen type I N-terminal propeptide released to the serum under these conditions.