ISBN: 978-93-87500-57-0
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Published Chapters:
Arginine Substituted Phthalocyanine with Positive Charge in Wide pH Range asEfficient Photosensitizer for Photodynamic Therapy
Author(s) :Kang Sun*
Drugs with positive charge usually have good water solubility, enhanced cellular uptake efficiency and activity. However, the preparation of quaternized drugs need potentially dangerous agents, while protonated cationic drugs are easily deprotonated in alkaline solutions. Arginine can be positively charged in a wide range of pH. Thus, two phthalocyanine-arginine conjugates (ArgEZnPc and ArgZnPc) were reported in this paper. They can be positively charged in the range of pH 5 to 9. Besides, the photochemical and photobiological properties, subcellular localization, anticancer activities of the them were also carried out. The results show that ArgEZnPc has high water solubility, excellent singlet oxygen and reactive oxygen species generation efficiency, can preferentially localize in the lysosomes of HeLa cells.
Biological Activity Prediction in Computational Drug Design: Focusing Attention on the Neural Network and Deep Learning Algorithms
Author(s) :Fahimeh Ghasemi
Because of naturally time-consuming, complex and costly processes of laboratory procedures, two last decades can be regarded as the golden period of using mathematical or statistical methods in computational drug design as an alternative approach, called Quantitative Structure−Activity Relationship (QSAR). QSAR studies are depended on the 2D and 3D molecular representation as an input model to predict biological activities. Biological activity is a beneficial or side effects of a drug on living matter that plays a critical roles in medical applications. Molecular representations, frequently well-known as molecular descriptors, have been converted to the useful numerical information via mathematical procedures.
Developing a Handheld Color Sensor Module to Monitor the Physiological Status of the Human Cardiovascular System in Vivo
Author(s) :Jung Y. Huang*; Chien-Yu Hsu
A sensitive color sensor module is developed to probe the physiological status of the human cardiovascular system. Breathing rhythm and heartbeat activity are observed in real time. The skin lightness and skin color expressed in the L*a*b* color coordinate system fluctuate due to changes in blood perfusion according to the rhythm of the heartbeat. Using a Gaussian mixture model, the cardiovascular system is found to fall into three physiological states. The state distribution profiles differ before and after physical exercise...
Electrospun Zein-based Nanofibrous Membranes for Biomedical Applications
Author(s) :Li-Ming Zhang*
The electro spunzein-baednanofibrous membranes have been shown great potential in tissue engineering, wound dressings and drug delivery. This article reviews the recent progress of nanofiber matrices electrospun from zein and natural polymers, zein and synthetic polymers, zein and crosslinking agents,zein-based conjugates as well as their biomedical applications.
