ISBN: 978-93-87500-66-2
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Published Chapters:
Zuojin Pill, a Classical Traditional Chinese Medicine Formula, Inhibits the Tafs-Induced Phenotype Transition and Migration in Normal Colonic Epithelial Cells Through TGF-Β/Smads Signaling
Author(s) :Chao Huang*; Xiu-lian Wang
Application of Traditional Chinese Medicine in clinic can go back more than 2,000 years. Recently, Chinese Medicine is reported to regulate remolding of tumor microenvironment (TME). However, the definite mechanisms are still unclear. Increasing studies have indicated that tumor-associated fibroblasts (TAFs) are crucial player in the TME remolding through inducing transdifferentiation of stromal cells. In our study, conditioned medium (CM) from TAF-like CCD-18Co cells stimulated the epithelial-mesenchymal transition (EMT) changes and enhanced the migration in colon epithelial cell line HCoEpiC, and these changes were suppressed by LY364947, a TGFβ receptor kinase I (TβRI) inhibitor...
