Biochemistry, also called as Biological Chemistry is the study of chemical processes of living organisms. It is a branch of science using chemical knowledge to understand and solve biological problems. Biochemistry has various applications in medicine and researchers are invited to submit their valuable work for the possible publication in an eBook entitled ADVANCES IN BIOCHEMISTRY & APPLICATIONS IN MEDICINE.
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Protein-protein interactions (PPIs) control a large number of biological processes. An attempt to design novel drug molecules has led to an increasing interest in the protein surfaces. Studying interaction interfaces in PPIs has set the stage for drug discovery to identify therapeutic agents for a range of human ailments. Inhibiting or stabilizing PPIs with small molecule drugs controls cellular behaviours significantly affecting disease outcomes. On one hand inhibiting PPIs can modulate pathological conditions, while on the other hand stabilizing certain PPIs can potentially treat diseases. It is, therefore, the calculated targeting of specific PPIs, with either small molecule inhibitors or stabilizers, which will have significant pharmacological value. PPIs control regulatory pathways and have been widely studied to design novel chemotherapeutics. Examples of certain small molecule drugs targeting PPIs involved in different biological pathways are discussed here in.
Nanotechnology is an emerging multidisciplinary field of science and technology that works at the molecular and atomic level. It has a major contribution in the development of key novel products in different regimes of science. In field of medicine, development of novel imaging agents, pharmaceutical nano-formulations are being developed for the betterment of the human health. Drug delivery using nanoparticles is an attractive advancement in medicine that enables targeted drug-delivery to attain attractive therapeutic efficacy. Recently used drug delivery system includes, polymeric micelles, liposomes, dendrimers and many others reveal a wide variety of useful properties. Conventional drug delivery methods represent several disadvantages because of off-target action and shows severe toxic health effects. Nanomedicine is an approach of nanotechnology, being applied for diagnosis and treatment of highly infectious diseases like cardiovascular diseases, Alzheimer's disease, Parkinson's disease, using nanoscale particles and nanorobots which is a major risk to mankind. Here, we provide a broad overview of nanoparticles, its novel applications, formulations and commercialization in the field of medicine using synthetic and natural nanopolymers.