An ebook on Biomedical Engineering

Home  /   eBooks
An ebook on Biomedical Engineering

Open Access eBooks

848 N. Rainbow Blvd, #5486,
Las Vegas, NV 89107, USA.


ISBN: 978-93-87500-57-0

Benefits of publishing with us:

Universal Access: eBooks published in Open Access eBooks gain international visibility. No region barriers and content is accessed by everyone across the world from our website. We also deposit published eBooks in different databases.

Freely Available: Open Access eBooks follows the principles of Open Access and the content is available to the readers without any cost. Readers can read, share, and store the published ebooks/book chapters.

Copyright with Authors: As an eBook publisher, we serve researchers in publishing their valuable work after the stringent review process. However, copyright lies with authors. We follow the CC-BY-NC-ND license (

Different Formats: We provide eBooks in PDF and HTML formats. Both formats are user friendly and can act as per the user requirements. We put our efforts to provide other formats in future.

For more information, contact

Published Chapters:

Arginine Substituted Phthalocyanine with Positive Charge in Wide pH Range asEfficient Photosensitizer for Photodynamic Therapy

Author(s) :Kang Sun*

Drugs with positive charge usually have good water solubility, enhanced cellular uptake efficiency and activity. However, the preparation of quaternized drugs need potentially dangerous agents, while protonated cationic drugs are easily deprotonated in alkaline solutions. Arginine can be positively charged in a wide range of pH. Thus, two phthalocyanine-arginine conjugates (ArgEZnPc and ArgZnPc) were reported in this paper. They can be positively charged in the range of pH 5 to 9. Besides, the photochemical and photobiological properties, subcellular localization, anticancer activities of the them were also carried out. The results show that ArgEZnPc has high water solubility, excellent singlet oxygen and reactive oxygen species generation efficiency, can preferentially localize in the lysosomes of HeLa cells.

New eBooks