Gastric Cancer, also called as stomach Cancer is a cancer developing in the lining of the stomach. It is very difficult to identify in the early stages. In later stages, it spreads to lungs, liver and other parts of the body. Gastric Cancer can be treated with chemotherapy, surgery, targeted therapy and radiation therapy. Researchers working in these areas are requested to contribute your work as a book chapter for the publication in volume 2 of an eBook entitled OVERVIEW ON GASTRIC CANCER.
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Each volume contains around 5 or 6 book chapters providing information on latest advances in gastric cancer.
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Management of tumours located at the esophagogastric junction remains a challenge for surgeons. These tumours can be managed as esophageal or gastric tumours and the available classifications are changing the therapeutic approach./The extent of surgery may vary depending on the stage of the tumour. There is a wide range of possibilities, from endoscopic resection to extended gastric and esophageal resection. Furthermore, the extent of lymphadenectomy is also controversial and different protocols are used in the East and West. Best neoadjuvant and adjuvant therapies remain unclear and are still being tested in an attempt to clarify which of them is the best option to improve the outcome of these patients. We discuss in this chapter the most recent published evidence and propose a management algorithm to treat this condition.
Gastric cancer (GC) is one of the leading causes of cancer death worldwide. Aberrant DNA methylation is closely associated with GC development. Understanding the comprehensive profiling of altered DNA methylation in different stages of gastric carcinogenesis will enable development of biomarkers for early detection, risk prediction, and allow for the development of novel targeted intervention strategies. Different DNA methylome mapping techniques are indispensable to realize this project in the future. We discuss in this chapter the recent published evidence and propose future perspectives on the DNA methylation changes in gastric carcinogenesis.
The initial evaluation of patients suspected of harboring gastric malignancy involves an upper gastrointestinal endoscopy, which provides information about the disease's anatomical site and helps obtain tissue samples for definitive histological diagnosis. After that, the accurate determination of the stage of the disease is essential to develop appropriate treatment strategies. The tumor, node, and metastasis (TNM) staging system of the eighth edition of the American Joint Committee on Cancer (AJCC) manual is currently the globally accepted standard for gastric cancer staging.
Gastric cancer is the sixth most common cancer worldwide, with higher mortality and morbidity. Surgery is an essential part of the multidisciplinary treatment of stomach cancer. The extent of lymphadenectomy that should accompany the resection of the primary tumor has been a controversial issue between Eastern and Western upper gastrointestinal surgeons in the surgical management of gastric cancer. East-Asian surgeons